Product: Anti-Human HSD11 beta 2 Antibody
Catalogue No.: 164514
Other Names: Hydroxysteroid 11-Beta Dehydrogenase 2, Short Chain Dehydrogenase/Reductase
Family 9C Member 3, NAD-Dependent 11-Beta-Hydroxysteroid Dehydrogenase, 11-Beta-Hydroxysteroid Dehydrogenase Type II, HSD11 Type II, AME1, HSD2, AME, 11-Beta-Hydroxysteroid Dehydrogenase Type 2, 11-Beta-HSD Type II, 11-HSD Type II, 11-Beta-HSD2, 11-DH2, HSD11K, SDR9C3, Short Chain Dehydrogenase/Reductase Family 9C, Member 3, Corticosteroid 11-Beta-Dehydrogenase Isozyme 2, Hydroxysteroid (11-Beta) Dehydrogenase 2, 11-Beta-HSD, EC 1.1.1., EC 1.1.1.
Description: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor
Immunogen: N-terminal peptide.
Clonality: Polyclonal IgG
Specificity: Human, Mouse, Rat, Rabbit. Other species not tested.
Concentration: >1.0 mg/mL IgG.
Purity: Affinity purified total rat IgG to >95% (by SDS PAGE).
Format: Provided as a sterile filtered solution in PBS, pH 7.2. No other additives.
Uses: ELISA, WB, IHC. Not tested for other uses.
Storage: Store at 4oC in fridge a for short term use. Aliquot and store at -20oC or -80oC for long term storage. Avoid repeated freeze thaw cycles.
Shipping: Antibody is shipped on ice pack at ambient temperature.