Product: Anti Mouse IFIT1 Monoclonal Antibody
Catalog No.: 831001
Alternate Names: Interferon-Induced Protein With Tetratricopeptide Repeats -1; IFIT1, IFIT, Interferon
Induced 56 kDA protein, IFI56, interferon alpha inducible protein, IFIT-1
Description: IFIT-1 is an Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear
a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses
Immunogen: Mouse IFIT-1 protein
Clone ID: 13B4-1
Isotype: IgG1, k
Specificity: Mouse IFIT-1, other species not tested
Concentration: >1mg/mL IgG.
Purity: Affinity purified mouse IgG to >95% (by SDS PAGE).
Format: Provided as a sterile filtered solution in PBS, pH 7.2. No other additives.
Applications: ELISA, WB, IHC, FACS. Not tested for other uses.
Storage: Store at 4oC in fridge a for short term use. Aliquot and store at -20oC or -80oC for long term storage. Avoid repeated freeze thaw cycles.
Shipping: Antibody is shipped on ice pack at ambient temperature.