Product Name: Anti IL13 Receptor Alpha 1 Monoclonal Antibody
Catalogue No.: 831089
Alternate Names: IL13RA1, IL13 Receptor Alpha 1, Interleukin 13 receptor alpha 1, NR4
Description: IL4 and IL13 are 2 cytokines that are secreted by activated T cells and have similar effects on monocytes and B cells. The amino acid sequences of IL4 and IL13 are approximately 30% homologous, and circular dichroism spectroscopy demonstrates that both proteins have a highly alpha-helical structure. IL13 competitively inhibited binding of IL4 to functional human IL4 receptors expressed on a cell line that responds to both IL4 and IL13. The binding of IL4 to an IL4-responsive cell line that does not respond to IL13, and the binding of IL4 to cloned IL4R ligand binding protein expressed on heterologous cells, were not inhibited by IL13. The results demonstrated that IL4 and IL13 share a receptor component that is important for signal transduction.
Specificity: Mouse. Other species not tested.
Shipping: Antibody is shipped on ice pack at ambient temperature.