Product: Anti PTRH2 Polyclonal Antibody
Catalogue No.: 583337
Other Names: PTRH2, BIT1, CFAP37, CGI-147, IMNEPD, PTH, PTH2, PTH2
Description: The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators.
Immunogen: Recombinant protein
Concentration: 1.0mg/mL IgG.
Purity: Affinity purified total rabbit IgG to >95% (by SDS PAGE).
Format: Provided as a sterile filtered solution in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. No other additives. Dilution IHC 1:50-1:200 IF 1:10-1:100.
Uses: IHC, IF. Not tested for other uses.
Storage: Store at 4oC in fridge for short term use. Aliquot and store at -20oC or -80oC for long term storage. Avoid repeated freeze thaw cycles. Centrifuge before opening to ensure complete recovery of vial contents.
Shipping: Antibody is shipped on ice pack at ambient temperature.