Product: Anti Ceramide Monoclonal Antibody
Catalog No.: 111583
Alternate Names: Ceramide
Description: Ceramide is an endogenous lipid component of a novel biochemical pathway termed the sphingomyelin pathway. It is generated by hydrolysis of membrane sphingomyelin by a unique magnesium independent, neutral, cytosolic sphingomyelinase. Ceramide is generated in response to cellular stimulation by hormones, cytokines and antigens. Mechanisms for ceramide action involve regulation of protein phosphorylation via stimulation of a serine/threonine protein phosphatase, a proline-directed kinase and possibly other direct and/or indirect targets. Ceramide metabolites such as sphingosine and sphingosine-1-phosphate have potent biological activities of their own. Ceramide appears to have a role in mediating biological responses in a wide variety of cell types. Ceramide is emerging as an intracellular messenger than mediates effects on terminal differentiation and cell proliferation as well as apoptosis or cell death and cell-cycle arrest.
Immunogen: Ceramide conjugated to carrier
Host: Mouse
Clonality Monoclonal
Isotype: IgG1 kappa
Concentration: 1mg/mL
Specificity: Ceramide.
Purity: Affinity purified total IgG to >95% (by SDS PAGE).
Format: Provided as a sterile filtered solution in PBS, pH 7.2. No additives, preservatives or stabilizers used.
Uses (Verified): ELISA. WB. IHC. Other uses not tested
Storage: Store at 4°C in fridge a for short term use. Aliquot and store at -20°C or -80°C for long term storage. Avoid repeated freeze thaw cycles.
Stability: 24 months at <-20°C.
Shipping: Antibody is shipped on ice pack at ambient temperature.
